Protein Details: Voltage-gated potassium channel subunit beta-2

Protein ID

ICDB_Pro_0662

Protein Name

Voltage-gated potassium channel subunit beta-2

Gene Name

Kcnab2; Ckbeta2; I2rf5; Kcnb3

Organism

Mus musculus (Mouse)

Length

367 amino acids

AlphaFoldDB

AF-P62482-F1-model_v4.pdb

Function

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling; and prevents neuronal hyperexcitability . Promotes expression of the pore-forming alpha subunits at the cell membrane; and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Modulates the functional properties of KCNA4 (By similarity). Modulates the functional properties of KCNA5. Enhances KCNB2 channel activity. Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal; 9;10-phenanthrenequinone; prostaglandin J2; 4-nitrobenzaldehyde; 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity)

Sequence

MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

56;57;63;85;158;188;189;214;243;244;245;246;247;248;254;262;264;323;325;329;332;333

Disease

Location

Detected in brain (PubMed:21357749). Detected at basket cell terminals in cerebellum and in the juxtaparanodal region of nodes of Ranvier (at protein level) (PubMed:11825900; PubMed:26269648). Strongest expression in brain and eye. Highest levels in brain detected in brainstem and diencephalon. Strong expression also detected in lung and heart. Moderate expression in kidney; T-lymphocytes and skeletal muscle

DOI ID

10.1074/jbc.271.5.2406; 10.1074/jbc.271.42.26341; 10.1002/jnr.490310208; 10.1101/gr.2596504; 10.1074/jbc.m111465200; 10.1111/j.1601-183x.2004.00094.x; 10.1016/j.cell.2010.12.001; 10.1083/jcb.201007113; 10.1523/jneurosci.2634-10.2011; 10.1074/mcp.o113.027870; 10.1523/jneurosci.1346-15.2015

RefSeq

NP_001239585.1; NP_034728.2; XP_017175485.1